In: Kumar CSSR (ed) Nanotechnologies for the life sciences. (2014) Biphase stratification approach to three-dimensional dendritic biodegradable mesoporous silica nanospheres. It is advised to only take Qsilica products when they are in-date. https://doi.org/10.1016/j.colsurfb.2013.02.027, Galdino FE, Picco AS, Sforca ML et al. The sweet spot is 0.5% w/w, which can be adjusted up or down depending on the required performance (the range varies between 0.2 and 1.0% w/w). (2020) Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules. ACS Appl Mater Interfaces 6:1260012608. https://doi.org/10.1016/j.jcis.2019.10.100, Yang SA, Choi S, Jeon SM, Yu J (2018) Silica nanoparticle stability in biological media revisited. https://doi.org/10.1021/j100812a002. Colloidal is used in reference to both pyrogenic and precipitated silica. Angew Chem Int Ed 49:62886308. (1991) Protein adsorption from human plasma is reduced on phospholipid polymers. V. The relative basicities of ethers, alkoxysilanes and siloxanes and the nature of the silicon-oxygen bond. It is not advisable to pre-mix Colloidal silica with lubricants, such as magnesium stearate or sodium stearyl fumarate. Colloidal silicon dioxide can be used in membrane-controlled and matrix-controlled transdermal drug delivery systems as a gel former or to increase storage and thermal stability. Qsilica liquid should be consumers within 8 weeks of opening. CAS Speciality granulated silica grades consisting of spherical particles in the range of 10100 m that feature a high internal surface (mesoporous) and high density can be used in the above-mentioned formulation strategies aimed at enhancing solubility and dissolution. The silica should be added first to ensure maximum mixing time. https://doi.org/10.1039/C6AY00419A, Bharti B, Meissner J, Findenegg GH (2011) Aggregation of silica nanoparticles directed by adsorption of lysozyme. Acta Biomater 84:317327. Anal Bioanal Chem 400:13671373. https://doi.org/10.1038/s41598-017-18502-8, Quignard S, Masse S, Laurent G, Coradin T (2013) Introduction of disulfide bridges within silica nanoparticles to control their intra-cellular degradation. J Sol-Gel Sci Technol 102, 4162 (2022). Convention, Food Chemicals Codex (11th Edition), (2018). For convenience, the different forms of Silica can be divided into three main groups as shown in the chart below: At the fundamental level of Silicas chemical properties is the Silica tetrahedron (SiO4), which consists of a central Silicon cation covalently bonded to four oxygen atoms, arranged in the shape of a tetrahedron. The maximum weight fraction of silica in the dispersion is limited based on the average particle size. Small 4:20252034. Wiley Interdiscip Rev Nanomed Nanobiotechnol 13:123. Pharm Res 33:23732387. Chem Phys Lett 191:327335. https://doi.org/10.1021/acsanm.0c02499, Keefe AJ, Jiang S (2012) Poly(zwitterionic)protein conjugates offer increased stability without sacrificing binding affinity or bioactivity. The authors declare no competing interests. Benefits of silica from Evonik for the pharmaceutical industry. Choosing the right colloidal silica can be a challenge. Nature 359:710712. https://doi.org/10.1039/C6TB00718J, Fontecave T, Sanchez C, Azas T, Boissire C (2012) Chemical modification as a versatile tool for tuning stability of silica based mesoporous carriers in biologically relevant conditions. Chem Commun 49:34103412. ACS Appl Mater Interfaces 9:1846218473. https://doi.org/10.1039/c7cs00316a, Anselmo AC, Mitragotri S (2015) A review of clinical translation of inorganic nanoparticles. The material can, in principle, be considered suitable for long-term storage and use when appropriately stored and handled. While the primary structure is the tetrahedron, consisting of one silicon atom bonded to four oxygen atoms, tetrahedrons arrange into networks. The Silica precipitates out as a slurry of (hydrated) silica, which is washed and filtered to remove by-products. https://doi.org/10.1007/s10971-021-05695-8, DOI: https://doi.org/10.1007/s10971-021-05695-8. The highest amount of colloidal silicon dioxide (hydrophilic) approved so far per dosage form can be found in the FDAs Inactive Ingredients Guide Database: http://www.accessdata.fda.gov/scripts/cder/iig/index.cfm. The orientation of the bonds is random, and there is no long-range periodicity. The subunits of colloidal silica particles are typically in the range of 1 to 5nm. It has been used in pharmaceuticals, food products, and cosmetics for over 50 years. Some material is published to support research and user education, and for the public good. J Colloid Interface Sci 227:408411. Opinion | What Does the Recent Pig-to-Human Kidney Transplant Mean for Tissue Therapeutics? Bull Chem Soc Jpn 89:501539. For a long time, Colloidal silicon dioxide was incorrectly associated with crystalline forms of silica since the two materials shared the same name and chemical formula. (2011) Photo-reversible supramolecular hyperbranched polymer based on hostguest interactions. Both effects are based on the ability of dispersed Colloidal silica particles to form a network of aggregates via hydrogen bridge linkage and/or van der Waals attractive forces in liquid media. Nanoscale 8:72407247. This case suggests that the drug vehicleanhydrous colloidal silicain the tablet formulations was the cause of the clinical picture, since this component was present in all tablets consumed. However, it should not be administered parenterally, because untoward tissue reactions or the formation of granulomas could occur. Colloidal silicon dioxide is used in tablet coating processes due to its ability to improve throughput and economics. John Wiley & Sons, Inc. Kosmulski M (2009) Compilation of PZC and IEP of sparingly soluble metal oxides and hydroxides from literature. Drug Development and Industrial Pharmacy 31 (2005) 687-696. A dust mask with particle filtering capability should be worn if high concentrations of dust are generated in the work environment. Colloidal silicon dioxide Anhydrous is a highly pure, very fine amorphous silicon dioxide having primary particles in the nano-scale range. https://doi.org/10.1039/C8CC05043K, Croissant JG, Fatieiev Y, Julfakyan K et al. Anal Chem 78:646654. Langmuir 27:1016710173. Hi I'm a vegan. (2007) Kinetic and thermodynamic studies of silica nanoparticle dissolution. J Phys Chem C 119:2735427362. Whether powder build-up is used, or only highly concentrated coating suspensions are used, Colloidal silicon dioxide is still useful for stabilising pigment suspension and improving a coatings smoothness. Silicon dioxide produced pyrogenically exists in the form of chain-like, branched aggregates, giving rise to a fluffy, light powder. J Sol-Gel Sci Technol 79:319327. Meanwhile, much stronger coats are obtained since the cores spend relatively shorter time periods in the coater. An example of such mesoporous Colloidal silicon dioxide is AEROPERL 300 Pharma (Evonik AG). Colloidal silica dispersions are fluid, low viscosity dispersions. ACS Sustain Chem Engeneering 5:48794889. Prog Polym Sci 17:163249. Qsilica Original Silica Liquid| Flora & Fauna. https://doi.org/10.1006/jcis.1994.1242, Adler JJ, Rabinovich YI, Moudgil BM (2001) Origins of the Non-DLVO force between glass surfaces in aqueous solution. Langmuir 22:43574362. Colloidal silicon dioxide is hygroscopic and absorbs significant amounts of water. Nat Nanotechnol 8:772781. There are many grades of colloidal silica, but all of them are composed of silica particles ranging in size from about 2 nm up to about 150 nm. Langmuir 36:1075610763. Agustin Silvio Picco or Mateus Borba Cardoso. https://doi.org/10.1016/0079-6700(92)90023-R, Muller P (1994) Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994). A colloid is a stable dispersion of particles - particles that are small enough that gravity doesn't cause them to settle, but large enough not to pass through a membrane and allow other molecules and ions to pass freely. Colloidal silicon dioxide improves powder flow by counteracting the forces behind particle cohesion. https://doi.org/10.1016/j.micromeso.2019.04.050, Allen LH, Matijevi E (1970) Stability of colloidal silica II. Thus, when the fumed silica is dispersed in a liquid, silanol groups interact with each other either directly or indirectly via the molecules in the liquid. It is not irritating to skin and eyes and passes through the gastrointestinal tract without being assimilated in detectable amounts. Silica is another name for silicon oxides - the most prevalent type being SiO2. Nonetheless, biological barriers can decrease the success of translating them for therapeutic applications since the media composition can induce their colloidal stability loss. (2018) Disulfide-bridged organosilica frameworks: designed, synthesis, redox-triggered biodegradation, and nanobiomedical applications. 2 0 obj<>/ColorSpace<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/ExtGState<>>> endobj There are no contraindications for silica during pregnancy or breastfeeding and therefore, with advice from your medical professional Qsilica ORIGINAL Skin, Hair, & Nails Capsules can be considered for use during pregnancy. The appearance of colloidal silica dispersion depends greatly on the particle size. Nat Chem 4:5963. According to the definition of ISO TS 80004-1, Colloidal silicon dioxide (and other synthetic amorphous silicas) are nanostructured. https://doi.org/10.1021/acsami.5b01900, Encinas N, Angulo M, Astorga C et al. The authors also acknowledge the financial support of the Fundao de Amparo Pesquisa do Estado de So Paulo (processes 2018/00763-8, 2019/24894-7, 2016/16905-0, 2020/00767-3, and 2015/25406-5). Qsilica ONE-A-DAY tablets are oval shaped and approximately 22mm long by 10mm wide. . Initial acidification of a water-glass (sodium silicate) solution yields Si(OH)4. (2018) Differential recognition of nanoparticle protein corona and modified low-density lipoprotein by macrophage receptor with collagenous structure. QSILICA ORIGINAL: Qsilica ORIGINAL Skin, Hair, & Nails Capsules contain only one active ingredient, colloidal mineral silica and does not contain any additional active ingredients. It is these aggregates that partly contribute to the unique functionalities of amorphous silicon dioxide. Nails Hair and Skin - Blackmores Subtledifferences in particle morphology, particle size, and ionicspecies can make all the difference. Nat Commun 8:110. Densified grades are not used to thicken oils because they form larger, more stable agglomerates that are difficult to disperse. J Colloid Interface Sci 292:139147. Chem Mater 28:90089016. Qsilica liquid should be stored below 25C before opened. [12] Jonat, S., Hasenzahl, S., Gray, A., Schmidt, P. C. Influence of compacted hydrophobic and hydrophilic colloidal silicon dioxide on tableting properties of pharmaceutical excipients. Belsito, R.A. Hill, C.D. Colloidal silicon dioxide does not pose any significant health effects to workers or end-users. (2008) Electrostatic self-assembly of PEG copolymers onto porous silica nanoparticles. [2] Evonik Industries, SIPERNAT and AEROSIL an essential in industrial powder technology, Technical information. Yes, the Qsilica capsules are created using a 2-part vegan capsule that contains colloidal silica powder. https://doi.org/10.1016/S0001-8686(02)00061-1, Bharti B, Meissner J, Klapp SHL, Findenegg GH (2014) Bridging interactions of proteins with silica nanoparticles: the influence of pH, ionic strength and protein concentration. It is distinct from other types of silicon dioxide, whether natural or synthetic, amorphous or crystalline. https://doi.org/10.1021/acs.langmuir.0c01545, Sun JT, Yu ZQ, Hong CY, Pan CY (2012) Biocompatible zwitterionic sulfobetaine copolymer-coated mesoporous silica nanoparticles for temperature-responsive drug release. Pyrogenic silica is produced in an anhydrous state, whereas the wet process products are obtained as hydrates or contain surface absorbed water (information required on hydrated silica, silica aerogel and colloidal silica) Assay: Content after ignition not less than 99.0% (fumed silica) or 94.0% (hydrated forms) https://doi.org/10.1021/acs.chemmater.9b00221, Choi E, Lim D-K, Kim S (2020) Hydrolytic surface erosion of mesoporous silica nanoparticles for efficient intracellular delivery of cytochrome c. J Colloid Interface Sci 560:416425. Use a high-shear mixer to disperse colloidal silicon dioxide in oils. And silica from Evonik can do much more: They can be used to reduce tablet weight without impacting stability. Adv Colloid Interface Sci 251:115138. https://doi.org/10.1016/j.jcis.2010.08.023, Kosmulski M (2018) The pH dependent surface charging and points of zero charge. J Colloid Interface Sci 390:3440. ;-mTU$o5$M4>-&mYu&1jx5kY* g.mzG'$^YiR? Adv Funct Mater 28:1707325. https://doi.org/10.1002/adfm.201707325, Fuentes C, Ruiz-Rico M, Fuentes A et al. Biomacromolecules 15:18451851. [4] M. Fuji, H. Iwata, T. Takei, T. Watanabe, M. Chikazawa, The change in the water vapor affinity of fine silica particles loaded with trimethylsilyl groups, Advanced Powder Technology, 8 (1997) 325-334. Adv Mater 22:11821195. https://doi.org/10.1007/978-3-642-72624-8_11, Kontogeorgis GM, Kiil S (2016) Introduction to applied colloid and surface chemistry. J Non Cryst Solids 104:95106. Evonik Industries, AEROSIL(R) Pharma Colloidal silicon dioxide, Technical information. The European Unions Scientific Committee on Food (SCF) concluded that silicon dioxide did not raise concerns with respect to genotoxicity. Some information contained on PharmaCentral.com may contain copyrighted material, the use of which may not have been specifically authorised by the respective copyright owners. Colloidal silicas exhibit particle densities in the range of 2.1 to 2.3 g/cm3. https://doi.org/10.1016/S0927-7757(01)00845-7, Hiemstra T, De Wit JC, Van Riemsdijk W (1989) Multisite proton adsorption modeling at the solid/solution interface of (hydr)oxides: a new approach. Providing markets with essential solutions, First some basic facts about silica - a truly versatile mineral. (2015) Organic modification of hydroxylated nanoparticles: silica, sepiolite, and polysaccharides. Adv Funct Mater 30:1909539. https://doi.org/10.1002/adfm.201909539, Stber W, Fink A, Bohn E (1968) Controlled growth of monodisperse silica spheres in the micron size range. https://doi.org/10.2217/nnm-2017-0280, Du X, Kleitz F, Li X et al. Naturally occurring in Quartz crystal, colloidal mineral silica (importantly, the element silicon contained within it) is the second most abundant element in the Earth's crust. Thus, it obviously alters the interactions of the particles with cellular and tissue components, ultimately modifying biological outcomes such as cellular uptake, immune-biocompatibility, and toxicity of NPs [39, 52,53,54]. https://doi.org/10.1351/pac199466051077, Estephan ZG, Jaber JA, Schlenoff JB (2010) Zwitterion-stabilized silica nanoparticles: toward nonstick nano. Parteck SLC is also emerging as a first-in-class excipient to reduce the risk of unstable . https://doi.org/10.1371/journal.pone.0141593, Saikia J, Yazdimamaghani M, Hadipour Moghaddam SP, Ghandehari H (2016) Differential protein adsorption and cellular uptake of silica nanoparticles based on size and porosity. Systemically acting drug products formulated as solid oral dosage forms necessarily require their active pharmaceutical ingredients (APIs) to dissolve in gastrointestinal juices before absorption into the bloodstream can occur. https://doi.org/10.1039/C5NR03065J, Croissant JG, Mauriello-Jimenez C, Maynadier M et al. (2020) Effect of particle functionalization and solution properties on the adsorption of bovine serum albumin and lysozyme onto silica nanoparticles. [6] L.C. (2020) Targeted manganese doped silica nano GSH-cleaner for treatment of liver cancer by destroying the intracellular redox homeostasis. Mater Horiz 6:10941121. Benefits of silica from Evonik for the pharmaceutical industry. Active ingredient per 10ml: Silica - colloidal anhydrous.280 mg (Equivalent to silicon 131 mg). https://doi.org/10.1021/cr900334y, Bobo D, Robinson KJ, Islam J et al. Colloidal silicon dioxide has a low risk of aging or decomposition. Whether you manufacture medicines for solid, semi-solid or liquid dosing, we support you at every stage of product development. (2019) Corona composition can affect the mechanisms cells use to internalize nanoparticles. mode: "every-time", Polydisperse suspensions can also be synthesized and have roughly the same limits in particle size. However, manufacturers recommend usage within two years of production for the following reasons: When handling colloidal silicon dioxide, dust formation cannot be fully prevented, thus dust extraction procedures are recommended. Selecting a Qsilica product is often a matter of personal preference. Adv Funct Mater 29:1904216. https://doi.org/10.1002/adfm.201904216, Lee JE, Lee N, Kim T et al. Synonym (s): Silica, colloidal anhydrous silica, colloidal silica, colloidal silicon dioxide, fumed silica, fumed silicon dioxide, highly disperse silicon dioxide, light anhydrous silicic acid, silica, Silicon dioxide Linear Formula: SiO2 CAS Number: 7631-86-9 Molecular Weight: 60.08 MDL number: MFCD00011232 https://doi.org/10.1038/nchem.1213, Garca KP, Zarschler K, Barbaro L et al. John Wiley & Sons, Brinker CJ, Scherer GW (1990) Sol-gel science. Adv Health Mater 7:1700831. https://doi.org/10.1002/adhm.201700831, Maggini L, Cabrera I, Ruiz-Carretero A et al. Our mostfrequently asked questions about products,results, health & more. We recommend selecting the Qsilica product that most closely suits your needs and therefore combining Qsilica products together should not be necessary. Colloidal silica -chemistry and characteristics. It may be produced by Stber process from Tetraethyl orthosilicate (TEOS). Therefore, APIs must first undergo dissolution in gastric juices and successfully permeate the lipid membrane of the intestinal wall. (2001) Alkali-treatment techniquenew method for modification of structural and acid-catalytic properties of ZSM-5 zeolites. However, the commercial production of Colloidal silicon dioxide uses copious amounts of energy across the entire value chain. *All claims with respect to conformity are subject to our Terms and Conditions. They do not cause silicosis. Colloidal stability and degradability of silica nanoparticles in Chem Rev 110:46564689. (2017) Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality. Colloidal silicon dioxide allows suspended particles to remain in suspension long enough until they are deposited on the substrate, for instance, the skin, or in the case of coatings, the tablet core. https://doi.org/10.1021/acs.langmuir.0c01571, Braun K, Pochert A, Beck M et al. Collagen provides a structural framework for skin by supporting its thickness and integrity. https://doi.org/10.1016/0021-9797(71)90203-7, Drescher D, Orts-Gil G, Laube G et al. Nanoscale 5:63726380. Australia's first and no.1 ingestible beauty brand. https://doi.org/10.1002/smll.202101519, Bhavsar D, Patel V, Sawant K (2019) Systemic investigation of in vitro and in vivo safety, toxicity and degradation of mesoporous silica nanoparticles synthesized using commercial sodium silicate. While liquids may be absorbed a little quicker, the disintegration of tablets or capsules is generally quite fast once the digestive process begins. (2017) Silica nanoparticles functionalized with Zwitterionic sulfobetaine siloxane for application as a versatile antifouling coating system. To differentiate between the different silica analogues, new CAS Registry numbers have been assigned. Powdered, liquid or pasty active ingredients should be first ground or triturated with Colloidal silicon dioxide and, if possible, sieved before being added to the molten suppository base. Angew Chem Int Ed 55:33233327. Rev Environ Sci Bio/Technol 1:1738. Both the European Union and the FDA have authorised the use of Colloidal silicon dioxide as a food additive and for food contact materials. A step toward the synthesis of hollow silica nanoparticles. All AEROSIL Pharma grades are manufactured according to IPEC GMP guidelines for bulk pharmaceutical excipients. Thickener for oils, Glidant and thickener applications but with reduced dusting and less volume requirements, Ideal glidant for hygroscopic powders that exhibit particle-particle cohesiveness via liquid bridge formation, LCO: 0.139 mg/L/4hr (maximal attainable concentration), The ability to coat formulation particles with a thin film of colloidal silicon dioxide aggregates, The ability to form gels in liquids by creating a three-dimensional network of colloidal silicon dioxide aggregates. https://doi.org/10.1002/smll.200800199, Zhu Y, Fang Y, Borchardt L, Kaskel S (2011) PEGylated hollow mesoporous silica nanoparticles as potential drug delivery vehicles. https://doi.org/10.1021/acsnano.8b02014, Yamamoto E, Kuroda K (2016) Colloidal mesoporous silica nanoparticles. https://doi.org/10.1021/ja107583h, Lara S, Perez-Potti A, Herda LM et al. Whether or not these subunits are joined together depends on the conditions of polymerization. The added organic groups are tightly bound to the surface (via covalent bonds) and are only broken via thermal decomposition. https://doi.org/10.1016/S0926-860X(01)00645-7, Rimer JD, Trofymluk O, Navrotsky A et al. https://doi.org/10.1016/0021-9797(89)90285-3, Sverjensky DA (2005) Prediction of surface charge on oxides in salt solutions: revisions for 1:1 (M+L-) electrolytes. Int J Pharm 361:177188. (2020) Targeted GSH-exhausting and hydroxyl radical self-producing manganesesilica nanomissiles for MRI guided ferroptotic cancer therapy. Finally, the viscosity of sodium silicates is much higher - closer to that of a syrup, while colloidal silicas have viscosities close to that of water. If more serious issues such as unusual hair loss or skin problems are the primary concerns, it is suggested that professional health care advice is sought - factors such as stress or hormonal imbalance may need to be considered. Each tablet contains a high quantity of active ingredient so only one-per-day is required. Langmuir 27:67946800. Colloids Surf B Biointerfaces 126:251256. If the pH is reduced below 7 or if salt is added, then the units tend to fuse together in chains. Be the first to know about exclusive offers, new products, expert tips and delicious recipes. Carrier for solid dispersions. (2015) Theranostic mesoporous silica nanoparticles biodegrade after pro-survival drug delivery and ultrasound/magnetic resonance imaging of stem cells. Vegetable Oil Hydrogenated Excipient | Uses, Suppliers, and Specifications, Magnesium Trisilicate Excipient | Uses, Suppliers, and Specifications, Hydrated Colloidal Silica Excipient | Uses, Suppliers, and Specifications, Kaolin Excipient | Uses, Suppliers, and Specifications, Magnesium Silicate Excipient | Uses, Suppliers, and Specifications, Under Section 107 of the Copyright Act 1976, Hydrophobic Colloidal Silica Excipient | Uses, Suppliers, and Specifications, Sodium Stearyl Fumarate Excipient | Uses, Suppliers, and Specifications, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, Monograph Silica, Colloidal Anhydrous, Fluffy, poorly flowing or free-flowing powder, Colloidal silica is hygroscopic. The only caveat is that the material must not come into contact with hydrofluoric acid or strong alkalis, as these chemical substances chemically react with silicon dioxide. Varying processing conditions allows the production of silica products with different specific surface areas, typically between 50 and 400 m2/g. Polydisperse suspensions can also be synthesized and have roughly the same limits in particle size. A summary of relevant toxicological data for Colloidal silicon dioxide is provided in the table below: The European Unions Scientific Committee on Food (SCF) and the Joint FAO/WHO Expert Committee on Food Additives assessed the safety of different silica products and established a group acceptable daily intake (ADI) for silicon dioxide as not specified. MORE, We are offering peanut-shaped, spherical and dry IDISIL Colloidal Silica grades in different particle sizes and with customized functionalization. Colloidal silicon dioxide has the chemical formula SiO2 but is distinct from other types of silica, such as amorphous or crystalline silica, that exist naturally or otherwise such as silica gel or precipitated silica. Chem Mater 31:43644378. [1] Evonik Industries, AEROSIL(R) Pharma Colloidal silicon dioxide, Technical information. Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in https://doi.org/10.1039/c9nr09879h, Hadipour Moghaddam SP, Mohammadpour R, Ghandehari H (2019) In vitro and in vivo evaluation of degradation, toxicity, biodistribution, and clearance of silica nanoparticles as a function of size, porosity, density, and composition. Our mostfrequently asked questions about products. https://doi.org/10.1016/j.jcis.2005.05.093, Harding RD (1971) Stability of silica dispersions. When silica is being handled, electrostatic charging can occasionally occur, for example when the silica sack is being emptied. (2020) Colloidal stability and redispersibility of mesoporous silica nanoparticles in biological media. ASP and MBC acknowledge UNLP and CONICET for their support. https://doi.org/10.1023/A:1015146710500, Ninham BW (1999) On progress in forces since the DLVO theory. https://doi.org/10.1021/la204913t, Hao N, Liu H, Li L et al. J Colloid Interface Sci 35:172174. https://doi.org/10.1016/j.micromeso.2019.02.033, Choi E, Kim S (2019) Surface pH buffering to promote degradation of mesoporous silica nanoparticles under a physiological condition. Crystalline forms of Silica exhibit a highly ordered crystal lattice, determined by the ordered arrangement of the Silica tetrahedra. Nanoscale 7:1504615050. Fumed silicon dioxide, in particular, has only one surface, which is external and little or non-existent internal pore volume. In addition, it increases the softening point of the suppository base without changing its melting point, an important property for improving stability in warm climates. * Granulated AEROPERL 300 Pharma does not fulfill the JP "Volume Test" due to its high bulk density, Versatile carrier for liquid or poorly soluble active pharmaceutical ingredients (API), Versatile auxiliary material for orally disintegrating tablets (ODT), Adjustment of rheology in semi-solid medications, Improved dissolution of individual active ingredients. (2015) Enzymatically degradable hybrid organicinorganic bridged silsesquioxane nanoparticles for in vitro imaging. item: "subscribe-3", https://doi.org/10.1016/j.actbio.2018.12.012, Scheffer FR, Silveira CP, Morais J et al. (2013) Dynamic development of the protein corona on silica nanoparticles: composition and role in toxicity. Effect of colloidal silica on rheological properties of common - PubMed The silica should be dispersed in the medium that contains the active ingredient, polymer (adhesive) and/or other excipients. Amorphous forms, on the other hand, have random, disordered lattices. J Am Chem Soc 83:761764. PDF SILICA, COLLOIDAL ANHYDROUS SILICA, COLLOIDAL HYDRATED - uspbpep.com Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, p 122, Parsegian VA (2005) Van Der Waals forces: a handbook for biologists, chemists, engineers, and physicists. Langmuir 25:31963199. In different pharmacopoeia, Anhydrous colloidal silicon dioxide is described as a fine, white, amorphous powder consisting of sub-microscopic particles (about 15 nm). J Inorg Nucl Chem 33:12931299. (2018) Surface chemical heterogeneity modulates silica surface hydration. (2012) Surface functionalization of silica nanoparticles supports colloidal stability in physiological media and facilitates internalization in cells. J Biomed Mater Res 25:13971407. The ability to adsorb substances onto the surface of the AEROSIL aggregates. Note that the aim of the MADG process is not to make large granules, but rather to agglomerate fines and bind the drug with excipients into freely flowing, compressible granules that can be tabletted without further processing. RSC Adv 3:17700. https://doi.org/10.1039/c3ra43098g, Tang H, Chen D, Li C et al. Several nonpolar liquids, such as vegetable oils, liquid paraffin and isopropyl myristate, can be converted into spreadable gels with Colloidal silicon dioxide.
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